AI Global Summit

Digital transformation represents a strategic lever for improving the access, quality, efficiency, and sustainability of the National Health Service (SSN). However, the adoption of digital technologies and AI-based solutions does not automatically translate into useful innovation: it requires solid evidence, public governance, value assessment, protection of equity, and integration into clinical-organizational processes. This presentation analyzes the opportunities and challenges of digitalizing Italian healthcare, highlighting the necessary conditions for technology to truly contribute to improving health outcomes, reducing inequalities, and strengthening a universal, fair, and sustainable healthcare system.

AI applied to voice opens new possibilities for the non-invasive monitoring of patient health. Through the automated analysis of vocal signals, it is possible to achieve early detection of alterations related to respiratory, neurological, or vocal disorders. This approach offers innovative diagnostic and monitoring solutions that can reach large populations and be seamlessly integrated into clinical and home-care pathways.

The quest to extend human healthspan and decode the biological mechanisms of aging is undergoing a profound transformation, driven by an inflection point in artificial intelligence. We are transitioning from a slow, observational approach in longevity science to a highly predictive, generative paradigm. I will explore how the convergence of advanced AI architectures and massive biological datasets is not just accelerating discovery, but fundamentally altering our approach to aging, cellular senescence, and age-related disease. At the foundation of this revolution are groundbreaking advances in biomolecular modeling and structural prediction. When coupled with emerging, purpose-built foundation models for biology and medicine, researchers are gaining the ability to decode intricate epigenetic and proteomic signatures. This enables the rational design of novel geroprotectors, targeted therapeutics, and highly personalized interventions with unprecedented speed and precision. However, the next frontier in longevity medicine lies in the transition from static structural mapping to dynamic biological simulation. The development of "world models" for biology and fully realized "virtual cells" represents a paradigm shift for the field. By simulating complex cellular behaviors and tissue-level interactions in silico, these dynamic models allow us to safely and rapidly test millions of potential anti-aging interventions. They enable researchers to predict complex systemic responses, model the long-term cascade of cellular aging, and evaluate multi-drug regimens without the immediate need for decades-long clinical trials.

In this keynote, Roberto Ascione explores the evolution of a vision that, over three decades, has helped transform digital health as we know it today. Drawing on the ideas presented in his book “The Future of Health”, he unpacks how the belief that digital technology could make care more accessible, sustainable, and human became a roadmap for innovation. With AI now accelerating every dimension of healthcare, from clinical decision support to patient engagement, from drug discovery to digital therapeutics, the keynote offers a clear perspective on how this transformation has taken shape over time. He shares lessons on which visionary ideas endured, how course corrections proved necessary, and why the most human ambitions, such as empowering patients, restoring the doctor patient relationship, and democratizing access, have proven the most durable. This is not a keynote about what’s coming. It’s the story of what has already arrived and what it took to get here.

Digital health is reshaping how primary care connects with patients beyond face-to-face visits. This presentation examines how general practitioners in Victoria, Australia integrate tools like SMS messaging into routine care to maintain relationships and support prevention. A case study on HPV vaccination outreach illustrates the potential of scalable, patient-centered digital interventions.

Talking about illnesses on social media? That’s exactly what patient communities do: 87% seek information online, 79% look for connections with others, and 76% compare experiences after medical visits. This trend highlights the growing importance of influential patients who, drawing from their own experiences, provide practical and emotional support to others. In the talk "Don’t Call Them Influencers", we will explore their role in online healthcare communication. 

Many AI initiatives in healthcare remain isolated chatbots or demos. ASP Siracusa proposes a different approach: designing AI as a governed component of clinical-organizational processes. The talk will demonstrate how prompt programming, orchestration, domain constraints, human-in-the-loop, and auditability enable the creation of more reliable and adoptable solutions. Participants will take away a concrete framework for designing high-value public AI.

Voice is one of the richest and least explored sources of data in healthcare: not only a tool for communication, but a biomarker capable of reflecting patients' physical and mental health. Through Artificial Intelligence techniques applied to voice analysis, it is now possible to transform speech into actionable insights at both a clinical level (early diagnosis, monitoring of neurological and respiratory diseases, psychological support) and an organizational level (optimization of triage flows, contact center interactions, automation of CUP/booking processes).The case study will show how integrating voice analysis AI models within digital healthcare ecosystems can:Improve the quality of care through predictive signals hidden in the voice.Enhance booking and support systems (CUP and call centers) with voice AI tools to reduce operational workloads.Provide new population metrics for public health (Population Health Management).

“Prevention is Life | Made For Life STORIES” is a social impact initiative that leverages communication to foster a culture of prevention, build relationships, and develop tangible projects within communities, while also promoting screening activities and awareness campaigns. Through real stories and a human-centered approach to healthcare and diagnostics, the project connects technology, communities, and people. It promotes a vision where diagnostics is not seen as an isolated technical procedure, but as an integral part of an ecosystem built on care, trust, and shared value.

With the release of ChatGPT and other generative artificial intelligence platforms, more and more people are turning to these systems for health-related answers. This phenomenon is set to grow with the launch of tools such as ChatGPT Health. However, scientific evidence suggests that it is crucial to use these technologies with caution and only within specific, controlled contexts. This session aims to clarify these aspects and provide a clearer perspective.

This talk dives into how AI is transforming healthcare from reactive, one‑size‑fits‑all delivery to truly personalised and predictive care. We’ll examine real‑world adoption patterns, the organisational and ethical challenges that slow progress, and how leading organisations have successfully navigated common pitfalls. The session will also feature a live demo of a human “digital twin,” illustrating how predictive insights can drive preventative, personalised care at scale.

Digital transformation and artificial intelligence are redefining the processes, skills, and responsibilities of healthcare professionals. However, international evidence highlights a persistent training gap that risks limiting the appropriate, safe, and equitable adoption of digital innovations. Based on data and analysis from the GIMBE National Health Service Observatory, this presentation offers a critical review of the Italian healthcare system's readiness. It emphasizes the role of scientific evidence, value assessment, and continuous professional development in governing Digital Health and transforming it into a real benefit for professionals, patients, and healthcare organizations.

A concrete case of digital transformation in healthcare: tele-dialysis at ASL Lecce. The presentation introduces the model of assisted home hemodialysis supported by telemedicine as an example of organizational innovation for frail nephrology patients. Through telemonitoring, clinical supervision, and community-based care, tele-dialysis improves continuity of care, personalization, sustainability, and quality of life, with a brief mention of the emerging role of artificial intelligence.

The objective of this speech is to provide a theoretical and scientific framework for telerehabilitation, illustrating its operating principles, delivery models, and the main evidence available in literature, which demonstrates how remote rehabilitation pathways can guarantee continuity of care, accessibility, and outcomes comparable to traditional rehabilitation across various clinical fields. The presentation will analyze the applications of telerehabilitation in major rehabilitative pathologies, focusing on neurological fields and highlighting the role of digital technologies, virtual reality, and robotic devices in improving therapeutic adherence, treatment customization, and functional outcomes. Furthermore, it will illustrate a corporate organizational model (AUSL Bologna and IRCCS ISNB) for the large-scale implementation of telerehabilitation, describing clinical-assistance processes, the integration between hospital and home settings, technological and professional requirements, as well as economic sustainability models and reimbursement mechanisms within the healthcare context. Concrete examples of implementation and technological innovation will be presented, with specific reference to PNC/PNRR-funded projects (won as Principal Investigator - PI) that integrate robotics and virtual reality into telerehabilitation, enabling more intensive, personalized, and engaging home-based treatments. Finally, the speech will highlight the future perspectives of digital rehabilitation, discussing opportunities, current limitations regarding standardization, security, and engagement, and the organizational and cultural challenges for the systemic adoption of these innovative models within healthcare systems.

How public healthcare facilities are positioned on Google Maps, and what can be done to improve their visibility.

To provide participants with a concrete perspective on how to evolve from simple digitization to the orchestration of healthcare processes, including through the use of dedicated tools. The objective is to understand how to integrate data, resources, and care pathways to generate measurable value, in alignment with the principles of Value-Based Healthcare, thereby improving efficiency and the quality of services.

Improving the prescriptive appropriateness of GPs (General Practitioners) with the support of an Artificial Intelligence (AI) algorithm. AI can reduce individual discretion and increase citizen trust in the NHS by supporting GPs in assigning the correct clinical priority for first-time NHS appointments. The AI dataset is based on RAO criteria.

Lecture dedicata a come l’intelligenza artificiale stia trasformando la gestione dell’arresto cardiaco e dell’emergenza-urgenza. Dalla previsione del rischio alla diagnosi precoce, dai wearable ai sistemi di allerta e dispatch, fino al supporto decisionale durante la rianimazione. Un viaggio tra evidenze, limiti etici e scenari realistici per integrare l’AI nella catena della sopravvivenza.

The project involved the implementation of a digital home care network for monitoring anticoagulant therapy with vitamin K antagonists (VKAs), developed in the metropolitan area of Bologna. These therapies, which are essential for preventing thromboembolic complications, require constant monitoring of the INR (International Normalized Ratio), a key parameter to ensure the treatment's efficacy and safety, particularly in elderly and frail patients. To meet this need, an innovative model based on Point of Care Testing (PoCT) was introduced, allowing the test to be performed directly at the patient's home. Nurses perform capillary blood sampling and analyze the sample using portable devices, obtaining rapid and reliable results comparable to those of a central laboratory.The system is supported by an integrated digital platform that connects local services with the laboratory and clinicians. Data is collected and managed in real time, and results undergo automatic validation processes using algorithms, ensuring high standards of quality and safety. The digital report is then made available to the physician, who can intervene promptly to adjust the therapy and schedule any subsequent checks. To date, the network involves numerous home care units and a large number of patients, with thousands of tests performed each year.One of the main advantages of this model is the significant reduction in turnaround time: from several hours required by the traditional model to just a few minutes with the home-based system. This translates into more efficient therapy management and a reduction in hospital admissions. Furthermore, the system ensures full traceability of the process, reducing the risk of pre-analytical errors and improving the overall safety of the diagnostic pathway. In conclusion, this experience demonstrates how the integration of digital technology and local healthcare can transform the management of chronic diseases, making care more accessible, timely, and patient-centered, with concrete benefits for both citizens and the healthcare system.

Digital health is growing fast, but instead of simplifying access, it has often increased fragmentation and complexity. AI Health risks amplifying this chaos if we don't fix the underlying issue: the lack of integration and a shared language across the healthcare system. This session explores the evolution from Digital Health to AI Health, highlighting its limits and opportunities. Through the Salute360 case study, we will see how to unify services, professionals, and patients into a single, accessible, and seamless experience.